BIOMOLECOLE DA BASIDIOMICETI COME SORGENTE DI POTENZIALI NUOVI FARMACI

Abstract

We reported the isolation and structural characterization of a new biogenetical related compounds, produced in cultures by various strains of Basidiomycetes of the genera Armillaria, Laurilia, Clitocybe and Clavicorona. The isolated metabolites are sesquiterpenoids containing the protoilludane ring system and are even correlated with some biological activity and biogenetic steps. We have analyzed the chemistry of the melleolides, sulcatines, tsugicolines and clavilactones. In particular, the spirolaxine, isolated from cultures of Sporotrichum laxum, is active on the bacterium Helicobacter pylori and is a potent inhibitor of angiogenesis. Its structure was determined on the basis of chemical and spectroscopic evidence and confirmed by X-ray analysis.