CARATTERIZZAZIONE MOLECOLARE E FUNZIONALE DI NEURONI STRIATALI DERIVATI DA CELLULE STAMINALI EMBRIONALI UMANE

Abstract

The development of neural differentiation protocol aimed at obtaining functional neurons in vitro represents the future in medicine. The text will explain the protocol developed by Cattaneolab in order to obtain in vitro striatal neurons from human embryonic and pluripotent stem cells. The work has been published in 2013 on Development (Delli Carri A., Onorati M., et al.; 2013). Striatal neurons at ganglia level die in Huntington’s Disease, a neurodegenerative disorder of the central nervous system, characterized by a gradual development of involuntary muscle movements, progressive disorientation and confusion, personality disintegration, impairment of memory control.