BIOMOLECOLE DA BASIDIOMICETI COME SORGENTE DI POTENZIALI NUOVI FARMACI

Autori

  • Gianluca Nasini CNR-Istituto di Chimica del Riconoscimento Molecolare. Dipartimento di Chimica, Materiali ed Ingegneria Chimica del Politecnico, Milano

DOI:

https://doi.org/10.4081/scie.2012.129

Abstract

We reported the isolation and structural characterization of a new biogenetical related compounds, produced in cultures by various strains of Basidiomycetes of the genera Armillaria, Laurilia, Clitocybe and Clavicorona. The isolated metabolites are sesquiterpenoids containing the protoilludane ring system and are even correlated with some biological activity and biogenetic steps. We have analyzed the chemistry of the melleolides, sulcatines, tsugicolines and clavilactones. In particular, the spirolaxine, isolated from cultures of Sporotrichum laxum, is active on the bacterium Helicobacter pylori and is a potent inhibitor of angiogenesis. Its structure was determined on the basis of chemical and spectroscopic evidence and confirmed by X-ray analysis.

Downloads

I dati di download non sono ancora disponibili.

##submission.downloads##

Pubblicato

2012-12-30

Come citare

Nasini, G. (2012). BIOMOLECOLE DA BASIDIOMICETI COME SORGENTE DI POTENZIALI NUOVI FARMACI. Istituto Lombardo - Accademia Di Scienze E Lettere - Rendiconti Di Scienze, 146. https://doi.org/10.4081/scie.2012.129